What is the principle of action of Fmoc-PEG

With the development of society, more and more people are getting diabetes nowadays, which is closely related to the lifestyle of people nowadays. People's living standard has improved, they eat well and eat a lot of fatty foods, and they do not like to exercise. In addition, the stressful nature of modern life and the fast pace of life are all risk factors for the development of diabetes. And Fmoc-PEG, as one of the medical intermediates for the treatment of diabetes drugs, plays a big role in this regard. So do you know how Fmoc-PEG works?

Here is the content list:

•The role of protecting groups

•Increasing the half-life of a drug in the body

The role of protecting groups

PEG is a safe, inactive, and non-toxic polymer that is commonly used for molecular modifications. In recent years, biomolecular drugs such as protein peptides and natural product drug molecules have been increasingly used in the field of disease treatment especially for chronic diseases, such as diabetes. However, the role of biomolecules in the medicinal process is greatly limited by their short half-life, Fmoc-PEG tendency to develop immunogenic antigenicity, their susceptibility to enzymatic degradation, and their pharmacological toxicity. The spatial hindrance of the polyethylene glycol chains makes the modified protein much more resistant to proteolytic enzymatic digestion, while the molecular exclusion volume of the modified molecule is significantly increased, resulting in a significant reduction in its renal filtration clearance. The structural specificity of Fmoc-PEG also reduces the ability of the hepatic reticuloendothelial system to recognize and clear the modified protein and reduces or eliminates the ability to induce neutralizing and binding antibodies, making it difficult to be recognized and cleared by the immune system.

Increasing the half-life of a drug in the body

The half-life of a drug can be referred to as the biological half-life or biological half-life, also abbreviated as "t1/2", and refers to the time it takes for the concentration of the drug in the blood or the amount of drug in the body to decrease to one-half. In clinical practice, the half-life of a drug can be used to guide the dosing of drugs. For drugs with a longer half-life, such as hypoglycaemic drugs with Fmoc-PEG, the dosing time should be longer, while for drugs with a shorter half-life, the dosing time should be shorter. The medication should be administered appropriately during this process. Do not shorten or extend the duration of the medication without permission, as this may cause adverse reactions or toxicity in patients. Fmoc-PEG prolongs the half-life of hypoglycaemic drugs in the patient's body, reducing the number of doses and to a certain extent the side effects.

These are some of the principles of the action of Fmoc-PEG. If you need Fmoc-PEG, you can consider our cost-effective products. Chengdu Pukang Biotechnology Co., Ltd are non-toxic and tasteless, perfect after-sales service, you can have no worries. Chengdu Pukang Biotechnology Co., Ltd was founded in 2008 and it is located in the national cross-strait science and technology industry development park——Cross-Strait Science and Technology Park, Wenjiang District, Chengdu，specializing in the long-term development of peptide drugs for chronic disease.